Details

Autor(en) / Beteiligte

• Taldone, Tony
• Zatorska, Danuta
• Kang, Yanlong
• Chiosis, Gabriela

Titel

A facile and efficient synthesis of d6-labeled PU-H71, a purine-scaffold Hsp90 inhibitor

Ist Teil von

• Journal of labelled compounds & radiopharmaceuticals, 2010-01, Vol.53 (1), p.47-49

Ort / Verlag

Chichester, UK: John Wiley & Sons, Ltd

Erscheinungsjahr

2010

Quelle

Wiley Online Library

Beschreibungen/Notizen

• PU‐H71 is a purine‐scaffold Hsp90 inhibitor currently undergoing late stage preclinical evaluation for the treatment of cancer. In this investigation, we present a simple method for the synthesis of d6‐labeled PU‐H71 for use as an internal standard to accurately quantitate the drug in biological matrices based on an LC‐MS‐MS method. PU‐H71‐d6 was synthesized in five steps using readily available 1,3‐dibromopropane‐d6 and is an important compound for the advancement of our clinical program. Copyright © 2009 John Wiley & Sons, Ltd. PU‐H71 is a purine‐scaffold Hsp90 inhibitor currently undergoing late stage preclinical evaluation for the treatment of cancer. In this investigation, we present a simple method for the synthesis of d6‐labeled PU‐H71 for use as an internal standard to accurately quantitate the drug in biological matrices based on an LC‐MS‐MS method. PU‐H71‐d6 was synthesized in five steps using readily available 1,3‐dibromopropane‐d6 and is an important compound for the advancement of our clinical program. Copyright © 2009 John Wiley & Sons, Ltd.