Clinical and experimental hypertension (1993), 1997, Vol.19 (8), p.1233-1246
1997
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- Autor(en) / Beteiligte
- Titel
- Sustained Diurnal Blood Pressure Reduction in SHR with Ramipril Assessed by Telemetric Monitoring
- Ist Teil von
- Clinical and experimental hypertension (1993), 1997, Vol.19 (8), p.1233-1246
- Ort / Verlag
- Colchester: Informa UK Ltd
- Erscheinungsjahr
- 1997
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Subchronic bolus administration of the angiotensin-converting-enzyme inhibitor ramipril caused a dose-dependent (0.1 to 10 mg.kg-1.d-1), yet each in his own way 24-hour sustained, reduction in arterial blood pressure in conscious unrestrained spontaneously hypertensive rats with tele-metric recording, and 0.01 mg.kg-1.d-1 was a no-effect dose. This was accompanied by dose-dependent attenuation of heart rate lowering during periods of low locomotor activity. Neither effect persisted for more than a few days after cessation of the medication with full restoration of pre-treatment levels. No dosage altered the circadian rhythm of blood pressure, heart rate and locomotor activity of the rats.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1064-1963eISSN: 1525-6006DOI: 10.3109/10641969709083215Titel-ID: cdi_pascalfrancis_primary_2055754
- Format
- –
- Schlagworte
- Analysis of Variance, Animals, Antihypertensive agents, Antihypertensive Agents - therapeutic use, Antihypertensive Agents - toxicity, Biological and medical sciences, Blood Pressure - drug effects, Blood Pressure Monitoring, Ambulatory - methods, cardiac reflex, Cardiovascular system, circadian, converting enzyme inhibition, Evaluation Studies as Topic, Heart Rate - drug effects, Hypertension - drug therapy, Male, Medical sciences, Motor Activity - drug effects, Pharmacology. Drug treatments, ramipril, Ramipril - therapeutic use, Ramipril - toxicity, Rats, Rats, Inbred SHR, Renin-Angiotensin System - drug effects, SHR, Telemetry