Details

Autor(en) / Beteiligte

• He, C.-Y.
• Li, W.-D.
• Guo, S.-X.
• Lin, S.-Q.
• Lin, Z.-B.

Titel

Effect of polysaccharides from Ganoderma lucidum on streptozotocin-induced diabetic nephropathy in mice

Ist Teil von

• Journal of asian natural products research, 2006-12, Vol.8 (8), p.705-711

Ort / Verlag

Abingdon: Taylor & Francis Group

Erscheinungsjahr

2006

Quelle

Taylor & Francis

Beschreibungen/Notizen

• The effects of Ganoderma lucidum polysaccharides (GL-PS) on renal complication in streptozotocin-induced diabetic mice have been investigated in the present study. C57BL/6J mice were made diabetic by injection of streptozotocin and GL-PS (125 and 250 mg kg − 1 ) was administered for 8 weeks. Body weight was monitored every week. Serum glucose, creatinine (Cr), blood urea nitrogen (BUN), triglyceride (TG) and urinary albumin excretion (UAE) were measured after 8 weeks of treatment. Glomerular size and mesangial matrix index were assayed by morphometric analysis. Renal expression of transforming growth factor-β 1 (TGF-β 1 ) were determined by immunochemistry. Renal malondialdehyde (MDA) level and superoxide dismutase (SOD) activities were also evaluated. GL-PS was able to reduce the serum Cr and BUN levels and UAE compared with diabetic model mice in a dose-dependent manner. Increasing serum glucose and triglyceride levels in diabetic mice could also be lowered by GL-PS. Moreover, GL-PS had the capacity to improve the renal morphometric changes and oxidative stress state of diabetic mice. In summary, GL-PS can improve the metabolic abnormalities of diabetic mice and prevent or delay the progression of diabetic renal complications.