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Characterization of Nitrile-hydrolyzing Enzymes Produced from Rhodococcus erythropolis
Ist Teil von
Han'gug mi'saengmul saengmyeong gong haghoeji, 2006-09, Vol.34 (3), p.204-210
Ort / Verlag
Seoul: Korean Society for Microbiology and Biotechnology
Erscheinungsjahr
2006
Quelle
EZB Electronic Journals Library
Beschreibungen/Notizen
Ethyl (S)-4-chloro-3-hydroxybutyronitrile is a useful intermediate for the synthesis of Atorvastatin, a chiral drug to hypercholesterolemia. In this research, two 4-chloro-3-hydroxybutyronitrile-degrading strains were isolated from soil sample. They were identified as Rhodococcus erythropolis strains by 16S rRNA analysis. the nitrile-degrading enzyme(s) were suggested to be nitrile hydratase and amidase rather than nitrilase from the result of thin layer chromatography analysis.