Details

Autor(en) / Beteiligte

• Park, H.J. (Catholic University of Daegu, Gyungsan, Republic of Korea)
• Uhm, K.N. (Equispharm, Ltd., iansan, Republic of Korea)
• Kim, H.K. (Catholic University of Daegu, Gyungsan, Republic of Korea), E-mail: hkkim@catholic.ac.kr

Titel

Characterization of Nitrile-hydrolyzing Enzymes Produced from Rhodococcus erythropolis

Ist Teil von

• Han'gug mi'saengmul saengmyeong gong haghoeji, 2006-09, Vol.34 (3), p.204-210

Ort / Verlag

Seoul: Korean Society for Microbiology and Biotechnology

Erscheinungsjahr

2006

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Ethyl (S)-4-chloro-3-hydroxybutyronitrile is a useful intermediate for the synthesis of Atorvastatin, a chiral drug to hypercholesterolemia. In this research, two 4-chloro-3-hydroxybutyronitrile-degrading strains were isolated from soil sample. They were identified as Rhodococcus erythropolis strains by 16S rRNA analysis. the nitrile-degrading enzyme(s) were suggested to be nitrile hydratase and amidase rather than nitrilase from the result of thin layer chromatography analysis.