Journal of Clinical Microbiology, 2005-07, Vol.43 (7), p.3551-3554
2005
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- Fatal Reactivation of Postnatal Cytomegalovirus Infection with Rapid Emergence of Ganciclovir Resistance in an Infant after Allogeneic Stem Cell Transplantation
- Ist Teil von
- Journal of Clinical Microbiology, 2005-07, Vol.43 (7), p.3551-3554
- Ort / Verlag
- Washington, DC: American Society for Microbiology
- Erscheinungsjahr
- 2005
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Human cytomegalovirus (HCMV) can cause serious problems after hematopoietic stem cell transplantation. The death of a pediatric transplant recipient after reactivation of a postnatal HCMV infection with bilateral retinitis and pneumonitis is described. Sequencing of the HCMV UL97 region revealed a compartment-specific mutation (H520Q) in urine conferring ganciclovir resistance.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0095-1137eISSN: 1098-660XDOI: 10.1128/JCM.43.7.3551-3554.2005Titel-ID: cdi_pascalfrancis_primary_16930714
- Format
- –
- Schlagworte
- Antiviral Agents - pharmacology, Biological and medical sciences, Case Reports, Cytomegalovirus - drug effects, Cytomegalovirus - genetics, Cytomegalovirus - physiology, Cytomegalovirus Retinitis - virology, Fatal Outcome, Fundamental and applied biological sciences. Psychology, Hematopoietic Stem Cell Transplantation - adverse effects, Humans, Infant, Infectious diseases, Medical sciences, Microbiology, Phosphotransferases (Alcohol Group Acceptor) - genetics, Pneumonia - virology, Transplantation, Homologous - adverse effects, Virus Activation