Details

Autor(en) / Beteiligte

• REN, JASON Q.
• LI, LEI

Titel

ROD AND CONE SIGNALING TRANSMISSION IN THE RETINA OF ZEBRAFISH: AN ERG STUDY

Ist Teil von

• International journal of neuroscience, 2004-02, Vol.114 (2), p.259-270

Ort / Verlag

London: Informa UK Ltd

Erscheinungsjahr

2004

Quelle

EBSCOhost Psychology and Behavioral Sciences Collection

Beschreibungen/Notizen

• It has been suggested that in lower vertebrates, visual signals are propagated in the retina using mixed bipolar cell pathways. In this article, we examined rod and cone signaling transmission in the retina of teleost zebrafish. Full-field electroretinograms (ERGs) were recorded from the cornea of control or 2-amino-4-phosphonobutyric acid (APB)-treated zebrafish. During dark adaptation following bright light adaptation, the intensity-response (V-log I) curve for both the ERG b- and d-waves shifted. In control animals, the b-wave response displayed a typical visual Purkinje shift and became more sensitive. By contrast, the d-wave- became less sensitive. In the early dark adaptation, cone-dominant signals were readily recorded in both b- and d-waves. In the late dark adaptation, rod signals became dominant. However, no obvious d-wave was recorded. Intraocular injections of APB selectively blocked the b-wave, but revealed the d-wave in both early and late dark adaptation