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Grid technology is widely emerging. Still, there is an eminent shortage of real Grid users, due to the absence of two important catalysts: First, a widely accepted vision on how applications can substantially benefit from Grids, and second a toolkit of higher-level Grid services, tailored to application needs. The GridLab project aims to provide fundamentally new capabilities for applications to exploit the power of Grid computing, thus bridging the gap between application needs and existing Grid middleware. We present an overview of GridLab, a largescale, EU-funded Grid project spanning over a dozen groups in Europe and the US. We first outline our vision of Grid-empowered applications and then discuss GridLab’s general architecture.