Details

Autor(en) / Beteiligte

• Flamholz, Rachel
• Tran, Thuy
• Grad, Gary I.
• Mauer, Ann M.
• Olopade, Olufunmilayo I.
• Ellman, Michael H.
• McKinsey, James F.
• Jeon, Hye-Ran
• Baron, Joseph M.
• Baron, Beverly W.

Titel

Therapeutic plasma exchange for the acute management of the catastrophic antiphospholipid syndrome: β2-glycoprotein I antibodies as a marker of response to therapy

Ist Teil von

• Journal of clinical apheresis, 1999, Vol.14 (4), p.171-176

Ort / Verlag

New York: John Wiley & Sons, Inc

Erscheinungsjahr

1999

Quelle

Wiley-Blackwell subscription journals

Beschreibungen/Notizen

• We describe two patients with the catastrophic antiphospholipid syndrome associated with elevation of β2‐glycoprotein I antibodies and fulminant thrombotic diatheses. Both patients were treated with therapeutic plasma exchange (TPE), which resulted in a marked decrease in antibody titer accompanied by an improved clinical outcome in one patient (IgG antibody). In the second patient, the outcome was poor despite TPE (IgA antibody). There were no significant complications of TPE in either case. Because of the fulminant nature of the catastrophic antiphospholipid syndrome, we conclude that a trial of TPE is warranted for the acute management. Further studies are needed to clarify which patients may benefit from this treatment. J. Clin. Apheresis 14:171–176, 1999. © 1999 Wiley‐Liss, Inc.