Details

Autor(en) / Beteiligte

• Donaldson, D.H.
• Jones, C.
• Patterson, D.
• Britt, D.E.
• Jackson, C.L.

Titel

Localization of the gene for the ciliary neutrotrophic factor receptor (CNTFR) to human chromosome 9

Ist Teil von

• Genomics (San Diego, Calif.), 1993-09, Vol.17:3

Ort / Verlag

United States

Erscheinungsjahr

1993

Link zum Volltext

Quelle

Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)

Beschreibungen/Notizen

• Ciliary neurotrophic factor (CNTF) has recently been found to be important for the survival of motor neurons and has shown activity in animal models of amyotrophic lateral sclerosis (ALS). CNTF therefore holds promise as a treatment for ALS, and it and its receptor (CNTFR) are candidates for a gene involved in familial ALS. The CNTFR gene was mapped to chromosome 9 by PCR on a panel of human/CHO somatic cell hybrids and localized to 9p13 by PCR on a panel of radiation hybrids. 18 ref., 1 fig., 2 tabs.