Details

Autor(en) / Beteiligte

• Hsieh, Linda C
• Stephans, James C
• Schultz, Peter G

Titel

An Efficient Antibody-Catalyzed Oxygenation Reaction

Ist Teil von

• Journal of the American Chemical Society, 1994-03, Vol.116 (5), p.2167-2168

Ort / Verlag

Washington, DC: American Chemical Society

Erscheinungsjahr

1994

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Biological oxygen-transfer reactions are essential for the biosynthesis of steroids and neurotransmitters, the degradation of endogenous substances, and the detoxification of xenobiotics. The monooxygenase enzymes responsible for these transformations require biological cofactors such as flavin, heme and non-heme iron, copper, or pterin and typically utilize NADPH for cofactor regeneration. Given their biological and chemical importance, oxygenation reactions have long been targets for antibody catalysis, and in a few cases, redox-active heme and flavin-dependent antibodies have been characterized. More recently, a new strategy has emerged for the generation of catalytic antibodies which utilizes unnatural, chemical cofactors. We now report an antibody-catalyzed sulfide oxygenation reaction mediated by the chemical cofactor sodium periodate, with turnover numbers similar to those of the corresponding enzymatic reactions. (DBO)