Details

Autor(en) / Beteiligte

• Cooper, Penny
• Keer, Jacquie T.
• McCabe, Veronica M.
• Hamvas, Renata M.J.
• Brown, Stephen D.M.
• Rastan, Sohaila
• Brockdorff, Neil

Titel

Physical Mapping of 2000 kb of the Mouse X Chromosome in the Vicinity of the Xist Locus

Ist Teil von

• Genomics (San Diego, Calif.), 1993-03, Vol.15 (3), p.570-575

Ort / Verlag

San Diego, CA: Elsevier Inc

Erscheinungsjahr

1993

Quelle

Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)

Beschreibungen/Notizen

• A physical map encompassing approximately 2.0 megabases (Mb) in the region of the mouse X-inactivation center has been constructed. The map extends from the Gjb-1 locus to the Xist locus and demonstrates the order of probes inseparable by genetic analysis. The deduced locus order is as follows: Gjb-1, Ccg-1, DXCrc171, Rps4, Phka, DXCrc177, DXCrc318, Xist . Detailed physical mapping in the region between the Phka and Xist loci indicates the position of CpG-rich islands associated with the 5′ end of genes. The DXCrc177 and DXCrc318 loci, both defined by probes derived from linking clones, are associated with CpG-rich islands. The map provides a framework for the isolation of underlying sequences in the mouse X-inactivation center region.