Details

Autor(en) / Beteiligte

• Wooster, Richard
• Neuhausen, Susan L.
• Mangion, Jonathan
• Quirk, Yvette
• Ford, Deborah
• Collins, Nadine
• Nguyen, Kim
• Seal, Sheila
• Tran, Thao
• Averill, Diane
• Fields, Patty
• Marshall, Gill
• Narod, Steven
• Lenoir, Gilbert M.
• Lynch, Henry
• Feunteun, Jean
• Devilee, Peter
• Cornelisse, Cees J.
• Menko, Fred H.
• Daly, Peter A.
• Ormiston, Wilma
• McManus, Ross
• Pye, Carole
• Lewis, Cathryn M.
• Cannon-Albright, Lisa A.
• Peto, Julian
• Bruce A. J. Ponder
• Skolnick, Mark H.
• Easton, Douglas F.
• Goldgar, David E.
• Stratton, Michael R.

Titel

Localization of a Breast Cancer Susceptibility Gene, BRCA2, to Chromosome 13q12-13

Ist Teil von

• Science (American Association for the Advancement of Science), 1994-09, Vol.265 (5181), p.2088-2090

Ort / Verlag

Washington, DC: American Society for the Advancement of Science

Erscheinungsjahr

1994

Quelle

MEDLINE

Beschreibungen/Notizen

• A small proportion of breast cancer, in particular those cases arising at a young age, is due to the inheritance of dominant susceptibility genes conferring a high risk of the disease. A genomic linkage search was performed with 15 high-risk breast cancer families that were unlinked to the BRCA 1 locus on chromosome 17q21. This analysis localized a second breast cancer susceptibility locus, BRCA2, to a 6-centimorgan interval on chromosome 13q12-13. Preliminary evidence suggests that BRCA2 confers a high risk of breast cancer but, unlike BRCA 1, does not confer a substantially elevated risk of ovarian cancer.