Details

Autor(en) / Beteiligte

• Nordyke, Robert A
• Gilbert, Fred I., Jr

Titel

Optimal Iodine-131 Dose for Eliminating Hyperthyroidism in Graves' Disease

Ist Teil von

• The Journal of nuclear medicine (1978), 1991-03, Vol.32 (3), p.411-416

Ort / Verlag

Reston, VA: Soc Nuclear Med

Erscheinungsjahr

1991

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Since hypothyroidism is commonplace after treatment of Graves' disease with radioiodine, the goal should be cure of hyperthyroidism rather than avoidance of hypothyroidism. To find the optimal dose to accomplish cure, we treated 605 patients with stepwise increasing doses of 3, 4, 5, 6, 8, and 10 mCi, analyzing the relationship of dose, age, sex, gland weight, and thyroidal uptake to cure. Estimates of cure at doses above 10 mCi were made from the literature. Cure was directly related to dose between 5 and 10 mCi. There was no significant relationship between cure and age (chi-square, p = 0.74), sex (chi-square, p = 0.12), and 24-hr uptake if over 30% (chi-square for slope, p greater than 0.10). Cure and gland weight had an inverse relationship (chi-square for slope, 0.01 less than p less than 0.02). We concluded that the optimal 131I dose for curing hyperthyroidism is approximated by starting with 10 mCi and increasing it for unusually large glands or for special patient circumstances.