TAL2, A Helix-Loop-Helix Gene Activated by the (7;9)(q34;q32) Translocation in Human T-Cell Leukemia
1991
Details
- Autor(en) / Beteiligte
- Titel
- TAL2, A Helix-Loop-Helix Gene Activated by the (7;9)(q34;q32) Translocation in Human T-Cell Leukemia
- Ist Teil von
- Proceedings of the National Academy of Sciences - PNAS, 1991-12, Vol.88 (24), p.11416-11420
- Ort / Verlag
- Washington, DC: National Academy of Sciences of the United States of America
- Erscheinungsjahr
- 1991
- Link zum Volltext
- Quelle
- Free E-Journal (出版社公開部分のみ）
- Beschreibungen/Notizen
- Tumor-specific alteration of the TAL1 gene occurs in almost 25% of patients with T-cell acute lymphoblastic leukemia (T-ALL). We now report the identification of TAL2, a distinct gene that was isolated on the basis of its sequence homology with TAL1. The TAL2 gene is located 33 kilobase pairs from the chromosome 9 breakpoint of t(7;9)(q34;q32), a recurring translocation specifically associated with T-ALL. As a consequence of t(7;9)(q34;q32), TAL2 is juxtaposed with sequences from the T-cell receptor β-chain gene on chromosome 7. TAL2 sequences are actively transcribed in SUP-T3, a T-ALL cell line that harbors the t(7;9)(q34;q32). The TAL2 gene product includes a helix-loop-helix protein dimerization and DNA binding domain that is especially homologous to those encoded by the TAL1 and LYL1 protooncogenes. Hence, TAL2, TAL1, and LYL1 constitute a discrete subgroup of helix-loop-helix proteins, each of which can potentially contribute to the development of T-ALL.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0027-8424eISSN: 1091-6490DOI: 10.1073/pnas.88.24.11416Titel-ID: cdi_osti_scitechconnect_5827091
- Format
- –
- Schlagworte
- Acute T cell leukemia, Amino Acid Sequence, ANIMAL CELLS, Animals, Base Sequence, BASIC BIOLOGICAL SCIENCES, Basic Helix-Loop-Helix Transcription Factors, BETA DECAY RADIOISOTOPES, BETA-MINUS DECAY RADIOISOTOPES, Biological and medical sciences, BIOLOGICAL MATERIALS, BLOOD, BLOOD CELLS, BODY FLUIDS, Cell lines, CHEMICAL REACTIONS, CHROMOSOMAL ABERRATIONS, CHROMOSOMES, Chromosomes, Human, Pair 7, Chromosomes, Human, Pair 9, CONNECTIVE TISSUE CELLS, DAYS LIVING RADIOISOTOPES, DIMERIZATION, DISEASES, DNA, DNA HYBRIDIZATION, DNA probes, DNA SEQUENCING, DNA, Neoplasm - genetics, DNA, Neoplasm - isolation & purification, DNA-Binding Proteins - genetics, Fundamental and applied biological sciences. Psychology, Gene Expression Regulation, Neoplastic, GENES, Genetic Linkage, Genomics, HETEROCHROMOSOMES, Humans, HYBRIDIZATION, Hypoplastic left heart syndrome, IMMUNE SYSTEM DISEASES, ISOTOPES, LEUKEMIA, Leukemia, T-Cell - genetics, Leukemia-Lymphoma, Adult T-Cell - genetics, LEUKOCYTES, LIGHT NUCLEI, LYMPHOCYTES, MATERIALS, Mice, Molecular and cellular biology, MOLECULAR BIOLOGY, Molecular genetics, Molecular Sequence Data, MUTATIONS, Neoplasm Proteins - genetics, NEOPLASMS, NUCLEI, ODD-ODD NUCLEI, Oligodeoxyribonucleotides, Open Reading Frames, ORGANIC COMPOUNDS, PHOSPHORUS 32, PHOSPHORUS ISOTOPES, Polymerase Chain Reaction - methods, POLYMERIZATION, PROTEINS, Proto-Oncogenes, RADIOISOTOPES, Restriction Mapping, RNA, Sequence Homology, Nucleic Acid, SOMATIC CELLS, STRUCTURAL CHEMICAL ANALYSIS 550200 -- Biochemistry, T lymphocytes, Translocation, Genetic