Details

Autor(en) / Beteiligte

• Nechepurenko, I. V.
• Shirokova, E. D.
• Khvostov, M. V.
• Frolova, T. S.
• Sinitsyna, O. I.
• Maksimov, A. M.
• Bredikhin, R. A.
• Komarova, N. I.
• Fadeev, D. S.
• Luzina, O. A.
• Tolstikova, T. G.
• Salakhutdinova, N. F.

Titel

Synthesis, hypolipidemic and antifungal activity of tetrahydroberberrubine sulfonates

Ist Teil von

• Russian chemical bulletin, 2019-05, Vol.68 (5), p.1052-1060

Ort / Verlag

New York: Springer US

Erscheinungsjahr

2019

Quelle

Springer journals

Beschreibungen/Notizen

• The paper describes the synthesis of new tetrahydroberberrubine derivatives containing polyfl uorophenyl- or alkylsulfonate groups at the O(9) position as well as those containing or not containing a bromine atom at the C(12) position. In a model of acute Triton-induced hyperlipidemia, tetrahydroberberrubine 9- O -(heptafluoro-4’-toluene)sulfonate was shown to reduce the cholesterol level by 23.5%, which is comparable with the eff ect of Simvastatin. At a concentration of 32 μg mL −1 , tetrahydroberberrubine 9- O -pentafluorobenzenesulfonate inhibits the growth of the fungus Cryptococcus neoformans by 81.3±3.5%.