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Anti-Diabetic and Anti-Nephritic Activities of Grifola frondosa Mycelium Polysaccharides in Diet-Streptozotocin-Induced Diabetic Rats Via Modulation on Oxidative Stress
Ist Teil von
Applied biochemistry and biotechnology, 2019-01, Vol.187 (1), p.310-322
Ort / Verlag
New York: Springer US
Erscheinungsjahr
2019
Quelle
Alma/SFX Local Collection
Beschreibungen/Notizen
Grifola frondosa
is an edible fungus with a variety of potential pharmacological activities. This study investigates the hypoglycemic, anti-diabetic nephritic, and antioxidant properties of
G. frondosa
polysaccharides in diet-streptozotocin-induced diabetic rats. After a 4-week treatment with 100 mg/kg of metformin and 200 mg/kg of one of four different
G. frondosa
polysaccharide mixtures (especially GFPS3 and GFPS4), diabetic rats had enhanced body weight and suppressed plasma glucose, indicating the hypoglycemic activities of the
G. frondosa
polysaccharides.
G. frondosa
polysaccharides regulated the level of serum creatinine, blood urea nitrogen,
N
-acetyl-β-
d
-glucosaminidase, and albuminuria; inhibited the serum levels of interleukin (IL)-2, IL-6, and TNF-α; and enhanced the serum levels of matrix metalloproteinase 9 and interferon-α, confirming their anti-diabetic nephritic activities.
G. frondosa
polysaccharides ameliorated the pathological alterations in the kidneys of diabetic rats. Moreover,
G. frondosa
polysaccharides modulated the serum levels of oxidant factors such as superoxide dismutase, glutathione peroxidase, catalase, malondialdehyde, and reactive oxygen species, revealing their antioxidant properties. Furthermore, the administration of
G. frondosa
polysaccharides inhibited nuclear factor kappa B activities in the serum and kidneys. All of the data revealed that the activation of nuclear factor kappa B plays a central role in
G. frondosa
polysaccharide-mediated anti-diabetic and anti-nephritic activities.