Bulletin of experimental biology and medicine, 2019-02, Vol.166 (4), p.574-579
2019
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Details
- Autor(en) / Beteiligte
- Titel
- Effect of Extracellular Vesicles Formed by Multipotent Mesenchymal Stromal Cells on Irradiated Animals
- Ist Teil von
- Bulletin of experimental biology and medicine, 2019-02, Vol.166 (4), p.574-579
- Ort / Verlag
- New York: Springer US
- Erscheinungsjahr
- 2019
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- C57Bl/6J mice were exposed to γ-radiation in a dose of 7.5 Gy. A week later, the experimental group received intravenous injection of extracellular vesicles isolated from the culture medium of human bone marrow multipotent mesenchymal stromal cells. Changes in the physiological parameters of animals were assessed by laser correlation spectroscopy, histological examination, cytometry, and by differential leukocyte count. In 3 and 6 weeks, the parameters of the experimental group occupied an intermediate position between the intact and irradiated groups or did not differ significantly from the parameters of the intact group. The rate and efficiency of recovery varied at different levels of organization. Reduction of damage caused by irradiation in a sublethal dose at different levels of organization of experimental animals was shown.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0007-4888eISSN: 1573-8221DOI: 10.1007/s10517-019-04394-3Titel-ID: cdi_osti_scitechconnect_22927824
- Format
- –
- Schlagworte
- 60 APPLIED LIFE SCIENCES, Animals, B cells, BIOLOGICAL RECOVERY, Biomedical and Life Sciences, Biomedicine, Body Weight - radiation effects, BONE MARROW, Bone Marrow Cells - cytology, Bone Marrow Cells - radiation effects, Cell Biology, Cell culture, Cells, Cultured, CULTURE MEDIA, Cytometry, Extracellular vesicles, Extracellular Vesicles - metabolism, Gamma Rays, Humans, Internal Medicine, Intravenous administration, INTRAVENOUS INJECTION, IRRADIATION, Laboratory Medicine, LEUKOCYTES, Male, Mesenchymal stem cells, Mesenchymal Stem Cells - metabolism, Mesenchymal Stem Cells - radiation effects, Mesenchyme, MICE, Mice, Inbred C57BL, Pathology, Radiation (Physics), RADIATION DOSES, Spectroscopy, Stem cells, Stromal cells, Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine), γ Radiation