Applied biochemistry and biotechnology, 2019-11, Vol.189 (3), p.729-744
2019
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Details
- Autor(en) / Beteiligte
- Titel
- Photoprotective and Anti-Inflammatory Properties of Vina-Ginsenoside R7 Ameliorate Ultraviolet B-Induced Photodamage in Normal Human Dermal Fibroblasts
- Ist Teil von
- Applied biochemistry and biotechnology, 2019-11, Vol.189 (3), p.729-744
- Ort / Verlag
- New York: Springer US
- Erscheinungsjahr
- 2019
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Vina-ginsenoside R7 (R7) has been exhibited to engage in multiple pharmacological activities, such as antioxidant and anti-inflammatory activities. However, no photoaging-related studies have been performed on R7. Research is being conducted with the aim of assessing whether treatment with R7 has a protective effect on UVB-induced photoaging skin. Our results show that UVB exposure directly reduces matrix metalloproteinase (MMP) secretion through R7 by restraining the AP-1/MAPK pathway and blocks extracellular matrix (ECM) expression degradation. In addition, R7 improves the expression of transforming growth factor beta 1 (TGF-β1), and type I procollagen also facilitates the synthesis of collagen by the TGF-β/Smad signal transduction pathway. Finally, R7 valid blocks nuclear factor-κB (NF-κB) activation and enhances antioxidative stress capacity through activated nuclear factor (erythroid derived 2)-like 2 (Nrf2). In particular, the application of R7 restrains pro-inflammatory cytokines (TNF-α, IL-6, iNOS), which trigger ECM, degrade enzyme production, and suppress vascular endothelial growth factor (VEGF) secretion. In conclusion, R7 may constitute a promising cosmetic ingredient that can protect against skin photodamage resulting from detrimental UVB irradiation.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0273-2289eISSN: 1559-0291DOI: 10.1007/s12010-019-03027-9Titel-ID: cdi_osti_scitechconnect_22927512
- Format
- –
- Schlagworte
- 60 APPLIED LIFE SCIENCES, Anti-inflammatory agents, Anti-Inflammatory Agents - pharmacology, Antioxidants, Biochemistry, Biotechnology, Cell Line, Cell Survival - drug effects, Cell Survival - radiation effects, Chemistry, Chemistry and Materials Science, COLLAGEN, Collagen Type I - metabolism, Cytokines, Enzyme Activation - drug effects, Enzyme Activation - radiation effects, ENZYMES, Extracellular matrix, FIBROBLASTS, Fibroblasts - cytology, Fibroblasts - drug effects, Fibroblasts - metabolism, Fibroblasts - radiation effects, Gene Expression Regulation, Enzymologic - drug effects, Gene Expression Regulation, Enzymologic - radiation effects, Ginsenosides, Ginsenosides - pharmacology, Growth factors, Humans, INFLAMMATION, Interleukin 6, Interleukin-6 - metabolism, Intracellular Space - drug effects, Intracellular Space - metabolism, Intracellular Space - radiation effects, Irradiation, Luminescent Proteins - pharmacology, LYMPHOKINES, MAP kinase, Matrix metalloproteinase, Matrix Metalloproteinase 1 - genetics, Matrix Metalloproteinase 1 - metabolism, Matrix Metalloproteinase 3 - genetics, Matrix Metalloproteinase 3 - metabolism, Matrix metalloproteinases, Metalloproteinase, Mitogen-Activated Protein Kinases - metabolism, NF-kappa B - metabolism, NF-κB protein, Nitric-oxide synthase, Pharmacology, Procollagen, Proteolysis - drug effects, Proteolysis - radiation effects, Reactive Oxygen Species - metabolism, RNA, Messenger - genetics, RNA, Messenger - metabolism, Signal transduction, Signal Transduction - drug effects, Signal Transduction - radiation effects, SKIN, Skin - cytology, Skin - drug effects, Skin - radiation effects, Smad protein, SYNTHESIS, Transcription factors, Transforming Growth Factor beta1 - metabolism, Transforming growth factor-b1, Tumor necrosis factor-α, Ultraviolet radiation, Ultraviolet Rays - adverse effects, Vascular endothelial growth factor, Vascular Endothelial Growth Factor A - biosynthesis