Biochemical and biophysical research communications, 2016-05, Vol.473 (4), p.1078-1083
2016
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Details
- Autor(en) / Beteiligte
- Titel
- Aberrant localization of lamin B receptor (LBR) in cellular senescence in human cells
- Ist Teil von
- Biochemical and biophysical research communications, 2016-05, Vol.473 (4), p.1078-1083
- Ort / Verlag
- United States: Elsevier Inc
- Erscheinungsjahr
- 2016
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- 5-Bromodeoxyuridine (BrdU), a thymidine analogue, induces cellular senescence in mammalian cells. BrdU induces cellular senescence probably through the regulation of chromatin because BrdU destabilizes or disrupts nucleosome positioning and decondenses heterochromatin. Since heterochromatin is tethered to the nuclear periphery through the interaction with the nuclear envelope proteins, we examined the localization of the several nuclear envelope proteins such as lamins, lamin-interacting proteins, nuclear pore complex proteins, and nuclear transport proteins in senescent cells. We have shown here that lamin B receptor (LBR) showed a change in localization in both BrdU-induced and replicative senescent cells.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0006-291XeISSN: 1090-2104DOI: 10.1016/j.bbrc.2016.04.018Titel-ID: cdi_osti_scitechconnect_22598715
- Format
- –
- Schlagworte
- 5-Bromodeoxyuridine, 60 APPLIED LIFE SCIENCES, ANIMAL CELLS, Bromodeoxyuridine - pharmacology, BUDR, Cellular senescence, Cellular Senescence - physiology, Chromatin, HeLa Cells, HETEROCHROMATIN, Humans, Lamin B Receptor, Lamins - metabolism, LBR, Nuclear envelope, Nuclear Envelope - metabolism, Nuclear Envelope - ultrastructure, NUCLEOSOMES, RECEPTORS, Receptors, Cytoplasmic and Nuclear - metabolism, Subcellular Fractions - drug effects, Subcellular Fractions - metabolism, THYMIDINE, Tissue Distribution - drug effects