Details

Autor(en) / Beteiligte

• Haas, Rick L.M., M.D., Ph.D
• Girinsky, Theo, M.D., Ph.D
• Aleman, Berthe M.P., M.D., Ph.D
• Henry-Amar, Michel, M.D., Ph.D
• de Boer, Jan-Paul, M.D., Ph.D
• de Jong, Daphne, M.D., Ph.D

Titel

Low-Dose Involved-Field Radiotherapy as Alternative Treatment of Nodular Lymphocyte Predominance Hodgkin's Lymphoma

Ist Teil von

• International journal of radiation oncology, biology, physics, 2009-07, Vol.74 (4), p.1199-1202

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2009

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Purpose Nodular lymphocyte predominance Hodgkin's lymphoma is a very rare disease, characterized by an indolent clinical course, with sometimes very late relapses occurring in a minority of all patients. Considerable discussion is ongoing on the treatment of primary and relapsed disease. Patients and Methods A group of 9 patients were irradiated to a dose of 4 Gy on involved areas only. Results After a median follow-up of 37 months (range, 6–66), the overall response rate was 89%. Six patients had complete remission (67%), two had partial remission (22%), and one had stable disease (11%). Of 8 patients, 5 developed local relapse 9–57 months after radiotherapy. No toxicity was noted. Conclusion In nodular lymphocyte predominance Hodgkin's lymphoma, low-dose radiotherapy provided excellent response rates and lasting remissions without significant toxicity.