Details

Autor(en) / Beteiligte

• Chung, Hyun-Tai, Ph.D
• Kim, Dong Gyu, M.D., Ph.D
• Paek, Sun Ha, M.D
• Jung, Hee-Won, M.D

Titel

Development of Dose–Volume Relation Model for Gamma Knife Surgery of Non-Skull Base Intracranial Meningiomas

Ist Teil von

• International journal of radiation oncology, biology, physics, 2009-07, Vol.74 (4), p.1027-1032

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2009

Quelle

ScienceDirect

Beschreibungen/Notizen

• Purpose To provide a dose–volume relationship for gamma knife surgery (GKS) of non-skull base intracranial meningiomas. Methods and Materials The radiologic outcomes of GKS of 82 imaging-defined benign meningiomas located at non-skull base areas were analyzed. A total of 80 patients were included and all underwent treatment with GKS as the first and the only treatment modality. The mean patient age was 55.0 years (range, 26–78) and the mean tumor volume was 5.6 cm3 (range, 0.5–16.8). On average, 14.6 Gy (range, 10–20) was applied to the 50% isodose surface. The binary logistic regression method was applied to find prognostic factors of signal change (SC) on T2 -weighted magnetic resonance imaging after GKS. Results The actuarial tumor control rate was 91.6% at 5 years. A total of 29 lesions (35.4%) showed newly developed or aggravated SCs. The volume irradiated ≥14 Gy was the only statistically significant ( p < .01) prognostic factor of SC. A dose–volume relation model obtained from the cases without SC estimated a 12.2% SC probability. Conclusion This model can be used in GKS to treat small- to medium-size (<9.2 cm3 ) non-skull base meningiomas.