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We generalize modern ideas about the duality between Wilson loops and scattering amplitudes in N=4 super Yang-Mills theory to large-N (or quenched) QCD. We show that the area-law behavior of asymptotically large Wilson loops is dual to the Regge-Veneziano behavior of scattering amplitudes at high energies and fixed momentum transfer, when the quark mass is small and/or the number of particles is large. We elaborate on this duality for string theory in flat space, identifying the asymptotes of the disk amplitude and the Wilson loop of large-N QCD.