Details

Autor(en) / Beteiligte

• Kumari, Harshita
• Negin, Saeedeh
• Eisenhart, Andrew
• Patel, Mohit B
• Beck, Thomas L
• Heinrich, Frank
• Spikes, Helena J
• Gokel, George W

Titel

Assessment of a host-guest interaction in a bilayer membrane model

Ist Teil von

• RSC advances, 2022-11, Vol.12 (49), p.3246-3255

Ort / Verlag

Cambridge: Royal Society of Chemistry

Erscheinungsjahr

2022

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Supramolecular interactions are well recognized and many of them have been extensively studied in chemistry. The formation of supramolecular complexes that rely on weak force interactions are less well studied in bilayer membranes. Herein, a supported bilayer membrane is used to probe the penetration of a complex between tetracycline and a macrocyclic polyether. In a number of bacterial systems, the presence of the macrocycle has been found to significantly enhance the potency of the antimicrobial in vitro . The crown·tetracycline complex has been characterized in solution, neutron reflectometry has probed complex penetration, and the phenomena have been modeled by computational methods. Neutron reflectance and computational modeling reveal that a dialkyl lariat ether complexes tetracycline hydrochloride and enhances penetration into a model bilayer membrane.