Details

Autor(en) / Beteiligte

• Moon, Tae Seok

Titel

SynMADE: synthetic microbiota across diverse ecosystems

Ist Teil von

• Trends in biotechnology (Regular ed.), 2022-12, Vol.40 (12), p.1405-1414

Ort / Verlag

England: Elsevier Ltd

Erscheinungsjahr

2022

Quelle

Access via ScienceDirect (Elsevier)

Beschreibungen/Notizen

• The past two decades have witnessed rapid advances in engineering individual microbial strains to produce biochemicals and biomaterials. However, engineering microbial consortia has been relatively slow. Using systems and synthetic biology approaches, researchers have been developing tools for engineering complex microbiota. In this opinion article, I discuss future directions and visions regarding developing microbiota as a biomanufacturing host. Specifically, I propose that we can develop the soil microbial community itself as a huge bioreactor. Ultimately, researchers will provide a generalizable system that enables us to understand a microbial consortium’s interaction and metabolism on diverse temporal and spatial scales to address global problems, including the climate crisis, food inequality, the issue of waste, and sustainable bioproduction. Recent technological advances enable microbiota engineering for sustainable biomanufacturing.Soil can be viewed as a huge bioreactor to capture carbon dioxide and provide nutrients (e.g., fixed nitrogen) and high-value chemicals and materials.Soil communities are complex, making them a challenge to understand and engineer.This opinion article provides a generalized approach to understanding and engineering the interactions and metabolism in microbial consortia on diverse temporal and spatial scales to address global problems, including the climate crisis, food inequality, waste issues, and sustainable bioproduction.