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Insights into the photoprotection mechanism of the UV filter homosalate
Ist Teil von
Physical chemistry chemical physics : PCCP, 2020-07, Vol.22 (27), p.1559-15519
Ort / Verlag
England: Royal Society of Chemistry
Erscheinungsjahr
2020
Quelle
MEDLINE
Beschreibungen/Notizen
Homosalate (HMS) is a salicylate molecule that is commonly included within commercial sunscreen formulations to provide protection from the adverse effects of ultraviolet (UV) radiation exposure. In the present work, the mechanisms by which HMS provides UV photoprotection are unravelled, using a multi-pronged approach involving a combination of time-resolved ultrafast laser spectroscopy in the gas-phase and in solution, laser-induced fluorescence, steady-state absorption spectroscopy, and computational methods. The unique combination of these techniques allow us to show that the
enol
tautomer of HMS undergoes ultrafast excited state intramolecular proton transfer (ESIPT) upon photoexcitation in the UVB (290-320 nm) region; once in the
keto
tautomer, the excess energy is predominantly dissipated non-radiatively. Sharp transitions are observed in the LIF spectrum at close-to-origin excitation energies, which points towards the potential presence of a second conformer that does not undergo ESIPT. These studies demonstrate that, overall, HMS exhibits mostly favourable photophysical characteristics of a UV filter for inclusion in sunscreen formulations.
Homosalate has been found to exhibit favourable photophysics for inclusion in sunscreens, using a combination of spectroscopic and computational approaches.