Details

Autor(en) / Beteiligte

• Tran, H.N.
• Karamitros, M.
• Ivanchenko, V.N.
• Guatelli, S.
• McKinnon, S.
• Murakami, K.
• Sasaki, T.
• Okada, S.
• Bordage, M.C.
• Francis, Z.
• El Bitar, Z.
• Bernal, M.A.
• Shin, J.I.
• Lee, S.B.
• Barberet, Ph
• Tran, T.T.
• Brown, J.M.C.
• Nhan Hao, T.V.
• Incerti, S.

Titel

Geant4 Monte Carlo simulation of absorbed dose and radiolysis yields enhancement from a gold nanoparticle under MeV proton irradiation

Ist Teil von

• Nuclear instruments & methods in physics research. Section B, Beam interactions with materials and atoms, 2016-04, Vol.373 (C), p.126-139

Ort / Verlag

Netherlands: Elsevier B.V

Erscheinungsjahr

2016

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Gold nanoparticles have been reported as a possible radio-sensitizer agent in radiation therapy due to their ability to increase energy deposition and subsequent direct damage to cells and DNA within their local vicinity. Moreover, this increase in energy deposition also results in an increase of the radiochemical yields. In this work we present, for the first time, an in silico investigation, based on the general purpose Monte Carlo simulation toolkit Geant4, into energy deposition and radical species production around a spherical gold nanoparticle 50nm in diameter via proton irradiation. Simulations were preformed for incident proton energies ranging from 2 to 170MeV, which are of interest for clinical proton therapy.