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We report on magnetotransport experiments investigating the effect of a regular array of nanoscale holes on the anisotropic response in the transition temperature of a superconducting niobium thin film. We find that the angle dependence of the critical temperature exhibits two strong anisotropic effects: Little-Parks oscillations whose period varies with field direction and a smooth background arising from one-dimensional confinement by the finite lateral space between neighboring holes. The two components of the anisotropy are intrinsically linked and appear in concert with one superimposed on top of the other.