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Selective photothermolysis to target sebaceous glands: Theoretical estimation of parameters and preliminary results using a free electron laser
Lasers in surgery and medicine, 2012-02, Vol.44 (2), p.175-183
Sakamoto, Fernanda H.
Doukas, Apostolos G.
Farinelli, William A.
Tannous, Zeina
Shinn, Michelle
Benson, Steve
Williams, Gwyn P.
Gubeli III, Joseph F.
Dylla, H. Frederick
Anderson, R. Rox
2012
Details
Autor(en) / Beteiligte
Sakamoto, Fernanda H.
Doukas, Apostolos G.
Farinelli, William A.
Tannous, Zeina
Shinn, Michelle
Benson, Steve
Williams, Gwyn P.
Gubeli III, Joseph F.
Dylla, H. Frederick
Anderson, R. Rox
Titel
Selective photothermolysis to target sebaceous glands: Theoretical estimation of parameters and preliminary results using a free electron laser
Ist Teil von
Lasers in surgery and medicine, 2012-02, Vol.44 (2), p.175-183
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2012
Link zum Volltext
Quelle
Wiley Online Library - AutoHoldings Journals
Beschreibungen/Notizen
Background and Objectives The success of permanent laser hair removal suggests that selective photothermolysis (SP) of sebaceous glands, another part of hair follicles, may also have merit. About 30% of sebum consists of fats with copious CH2 bond content. SP was studied in vitro, using free electron laser (FEL) pulses at an infrared CH2 vibrational absorption wavelength band. Methods Absorption spectra of natural and artificially prepared sebum were measured from 200 to 3,000 nm, to determine wavelengths potentially able to target sebaceous glands. The Jefferson National Accelerator superconducting FEL was used to measure photothermal excitation of aqueous gels, artificial sebum, pig skin, human scalp, and forehead skin (sebaceous sites). In vitro skin samples were exposed to FEL pulses from 1,620 to 1,720 nm, spot diameter 7–9.5 mm with exposure through a cold 4°C sapphire window in contact with the skin. Exposed and control tissue samples were stained using H&E, and nitroblue tetrazolium chloride staining (NBTC) was used to detect thermal denaturation. Results Natural and artificial sebum both had absorption peaks near 1,210, 1,728, 1,760, 2,306 and 2,346 nm. Laser‐induced heating of artificial sebum was approximately twice that of water at 1,710 and 1,720 nm, and about 1.5× higher in human sebaceous glands than in water. Thermal camera imaging showed transient focal heating near sebaceous hair follicles. Histologically, skin samples exposed to ∼1,700 nm, ∼100–125 milliseconds pulses showed evidence of selective thermal damage to sebaceous glands. Sebaceous glands were positive for NBTC staining, without evidence of selective loss in samples exposed to the laser. Epidermis was undamaged in all samples. Conclusions SP of sebaceous glands appears to be feasible. Potentially, optical pulses at ∼1,720 or ∼1,210 nm delivered with large beam diameter and appropriate skin cooling in approximately 0.1 seconds may provide an alternative treatment for acne. Lasers Surg. Med. 44:175–183, 2012. © 2012 Wiley Periodicals, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 0196-8092
eISSN: 1096-9101
DOI: 10.1002/lsm.21132
Titel-ID: cdi_osti_scitechconnect_1039896
Format
–
Schlagworte
60 APPLIED LIFE SCIENCES
,
ABSORPTION
,
ABSORPTION SPECTRA
,
acne
,
Animals
,
BASIC BIOLOGICAL SCIENCES
,
CAMERAS
,
CHLORIDES
,
EPIDERMIS
,
EXCITATION
,
free electron laser
,
FREE ELECTRON LASERS
,
GLANDS
,
HAIR
,
HAIR FOLLICLES
,
HEATING
,
Humans
,
IN VITRO
,
In Vitro Techniques
,
laser
,
LASERS
,
light
,
Male
,
Monte Carlo Method
,
near infrared
,
Pilot Projects
,
REMOVAL
,
Sebaceous Glands - chemistry
,
Sebaceous Glands - radiation effects
,
Sebum - chemistry
,
Sebum - radiation effects
,
SKIN
,
Skin - chemistry
,
Skin - radiation effects
,
Spectrophotometry
,
spectroscopy
,
Swine
,
TARGETS
,
TETRAZOLIUM
,
therapy
,
TRANSIENTS
,
Water - chemistry
,
WAVELENGTHS
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