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Remdesivir for the treatment of Covid-19: the value of biochemical studies

Current opinion in virology, 2021-08, Vol.49, p.81-85

Götte, Matthias

2021

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Direct-acting antiviral agents for hepatitis C: structural and mechanistic insights

Nature reviews. Gastroenterology & hepatology, 2016-06, Vol.13 (6), p.338

2016

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The antiviral compound remdesivir potently inhibits RNA-dependent RNA polymerase from Middle East respiratory syndrome coronavirus

The Journal of biological chemistry, 2020-04, Vol.295 (15), p.4773-4779

2020

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Mechanism of Inhibition of Ebola Virus RNA-Dependent RNA Polymerase by Remdesivir

Viruses, 2019-04, Vol.11 (4), p.326

2019

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Molnupiravir promotes SARS-CoV-2 mutagenesis via the RNA template

The Journal of biological chemistry, 2021-07, Vol.297 (1), p.100770-100770, Article 100770

2021

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Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome coronavirus 2 with high potency

The Journal of biological chemistry, 2020-05, Vol.295 (20), p.6785-6797

2020

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Zika Virus Hijacks Stress Granule Proteins and Modulates the Host Stress Response

Journal of virology, 2017-08, Vol.91 (16)

2017

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Theoretical investigation of the applicability of the Meservey-Tedrow technique to the surface states of topological insulators

New journal of physics, 2019-12, Vol.21 (12), p.123042

2019

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Template-dependent inhibition of coronavirus RNA-dependent RNA polymerase by remdesivir reveals a second mechanism of action

The Journal of biological chemistry, 2020-11, Vol.295 (47), p.16156-16165

2020

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Recombinant RNA-Dependent RNA Polymerase Complex of Ebola Virus

Scientific reports, 2018-03, Vol.8 (1), p.3970-9, Article 3970

2018

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Pure spin current devices based on ferromagnetic topological insulators

Scientific reports, 2016-10, Vol.6 (1), p.36070-36070, Article 36070

2016

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The active form of the influenza cap-snatching endonuclease inhibitor baloxavir marboxil is a tight binding inhibitor

The Journal of biological chemistry, 2021-01, Vol.296, p.100486-100486, Article 100486

2021

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Conformational Changes Spanning Angstroms to Nanometers via a Combined Protein-Induced Fluorescence Enhancement-Förster Resonance Energy Transfer Method

The journal of physical chemistry. B, 2017-03, Vol.121 (9), p.2039-2048

2017

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Mutations in the SARS-CoV-2 RNA-dependent RNA polymerase confer resistance to remdesivir by distinct mechanisms

Science translational medicine, 2022-08, Vol.14 (656), p.eabo0718

2022

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Resistance patterns associated with HCV NS5A inhibitors provide limited insight into drug binding

Viruses, 2014-11, Vol.6 (11), p.4227-4241

2014

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Human endogenous retrovirus-K (HERV-K) reverse transcriptase (RT) structure and biochemistry reveals remarkable similarities to HIV-1 RT and opportunities for HERV-K–specific inhibition

Proceedings of the National Academy of Sciences - PNAS, 2022-07, Vol.119 (27), p.1-e2200260119

2022

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The Nucleoside/Nucleotide Analogs Tenofovir and Emtricitabine Are Inactive against SARS-CoV-2

Molecules (Basel, Switzerland), 2022-06, Vol.27 (13), p.4212

2022

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Modular Assembly of Purine-like Bisphosphonates as Inhibitors of HIV‑1 Reverse Transcriptase

Journal of medicinal chemistry, 2014-09, Vol.57 (17), p.7435-7449

2014

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Remdesivir targets a structurally analogous region of the Ebola virus and SARS-CoV-2 polymerases

Proceedings of the National Academy of Sciences - PNAS, 2020-10, Vol.117 (43), p.26946-26954

2020

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Efficient incorporation and template-dependent polymerase inhibition are major determinants for the broad-spectrum antiviral activity of remdesivir

The Journal of biological chemistry, 2022-02, Vol.298 (2), p.101529-101529, Article 101529

2022

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Independent inhibition of the polymerase and deubiquitinase activities of the Crimean-Congo Hemorrhagic Fever Virus full-length L-protein

PLoS neglected tropical diseases, 2020-06, Vol.14 (6), p.e0008283-e0008283

2020

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Nucleic acid polymerases use a general acid for nucleotidyl transfer

Nature structural & molecular biology, 2009-02, Vol.16 (2), p.212-218

2009

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Contribution of a mutational bias in hepatitis C virus replication to the genetic barrier in the development of drug resistance

Proceedings of the National Academy of Sciences - PNAS, 2011-12, Vol.108 (51), p.20509-20513

2011

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Resistance to nucleotide analogue inhibitors of hepatitis C virus NS5B: mechanisms and clinical relevance

Current opinion in virology, 2014-10, Vol.8, p.104-108

Gotte, Matthias

2014

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Binding Kinetics and Affinities of Heterodimeric versus Homodimeric HIV‑1 Reverse Transcriptase on DNA–DNA Substrates at the Single-Molecule Level

The journal of physical chemistry. B, 2013-04, Vol.117 (16), p.4560-4567

2013

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Remdesivir for the treatment of Covid-19: the value of biochemical studies

Direct-acting antiviral agents for hepatitis C: structural and mechanistic insights

The antiviral compound remdesivir potently inhibits RNA-dependent RNA polymerase from Middle East respiratory syndrome coronavirus

Mechanism of Inhibition of Ebola Virus RNA-Dependent RNA Polymerase by Remdesivir

Molnupiravir promotes SARS-CoV-2 mutagenesis via the RNA template

Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome coronavirus 2 with high potency

Zika Virus Hijacks Stress Granule Proteins and Modulates the Host Stress Response

Theoretical investigation of the applicability of the Meservey-Tedrow technique to the surface states of topological insulators

Template-dependent inhibition of coronavirus RNA-dependent RNA polymerase by remdesivir reveals a second mechanism of action

Recombinant RNA-Dependent RNA Polymerase Complex of Ebola Virus

Pure spin current devices based on ferromagnetic topological insulators

The active form of the influenza cap-snatching endonuclease inhibitor baloxavir marboxil is a tight binding inhibitor

Conformational Changes Spanning Angstroms to Nanometers via a Combined Protein-Induced Fluorescence Enhancement-Förster Resonance Energy Transfer Method

Mutations in the SARS-CoV-2 RNA-dependent RNA polymerase confer resistance to remdesivir by distinct mechanisms

Resistance patterns associated with HCV NS5A inhibitors provide limited insight into drug binding

Human endogenous retrovirus-K (HERV-K) reverse transcriptase (RT) structure and biochemistry reveals remarkable similarities to HIV-1 RT and opportunities for HERV-K–specific inhibition

The Nucleoside/Nucleotide Analogs Tenofovir and Emtricitabine Are Inactive against SARS-CoV-2

Modular Assembly of Purine-like Bisphosphonates as Inhibitors of HIV‑1 Reverse Transcriptase

Remdesivir targets a structurally analogous region of the Ebola virus and SARS-CoV-2 polymerases

Efficient incorporation and template-dependent polymerase inhibition are major determinants for the broad-spectrum antiviral activity of remdesivir

Independent inhibition of the polymerase and deubiquitinase activities of the Crimean-Congo Hemorrhagic Fever Virus full-length L-protein

Nucleic acid polymerases use a general acid for nucleotidyl transfer

Contribution of a mutational bias in hepatitis C virus replication to the genetic barrier in the development of drug resistance

Resistance to nucleotide analogue inhibitors of hepatitis C virus NS5B: mechanisms and clinical relevance

Binding Kinetics and Affinities of Heterodimeric versus Homodimeric HIV‑1 Reverse Transcriptase on DNA–DNA Substrates at the Single-Molecule Level

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