Details

Autor(en) / Beteiligte

• Xiang Xu
• Yu-Nan Lu
• Jia-Hui Cheng
• Hui-Wen Lan
• Jing-Mei Lu
• Guang-Nan Jin
• Guang-Hua Xu
• Cheng-Hua Jin
• Juan Ma
• Hu-Nan Piao
• Xuejun Jin
• Lian-Xun Piao

Titel

Ginsenoside Rh2 reduces depression in offspring of mice with maternal toxoplasma infection during pregnancy by inhibiting microglial activation via the HMGB1/TLR4/NF-kB signaling pathway

Ist Teil von

• Journal of Ginseng Research, 2022, 46(1), , pp.62-70

Ort / Verlag

고려인삼학회

Erscheinungsjahr

2022

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Background: Maternal Toxoplasma gondii (T. gondii) infection during pregnancy has been associated withvarious mental illnesses in the offspring. Ginsenoside Rh2 (GRh2) is a major bioactive compound obtained from ginseng that has an anti-T. gondii effect and attenuates microglial activation through toll-likereceptor 4 (TLR4)/nuclear factor-kappa B (NF-kB) signaling pathway. GRh2 also alleviated tumorassociated or lipopolysaccharide-induced depression. However, the effects and potential mechanismsof GRh2 on depression-like behavior in mouse offspring caused by maternal T. gondii infection duringpregnancy have not been investigated. Methods: We examined GRh2 effects on the depression-like behavior in mouse offspring, caused bymaternal T. gondii infection during pregnancy, by measuring depression-like behaviors and assayingparameters at the neuronal and molecular level. Results: We showed that GRh2 significantly improved behavioral measures: sucrose consumption, forcedswim time and tail suspended immobility time of their offspring. These corresponded with increasedtissue concentrations of 5-hydroxytryptamine and dopamine, and attenuated indoleamine 2,3-dioxygenase or enhanced tyrosine hydroxylase expression in the prefrontal cortex. GRh2 amelioratedneuronal damage in the prefrontal cortex. Molecular docking results revealed that GRh2 binds strongly toboth TLR4 and high mobility group box 1 (HMGB1). Conclusion: This study demonstrated that GRh2 ameliorated the depression-like behavior in mouseoffspring of maternal T. gondii infection during pregnancy by attenuating the excessive activation ofmicroglia and neuroinflammation through the HMGB1/TLR4/NF-kB signaling pathway. It suggests thatGRh2 could be considered a potential therapy in preventing and treating psychiatric disorders in theoffspring mice of mothers with prenatal exposure to T. gondii infection. KCI Citation Count: 9