Details

Autor(en) / Beteiligte

• Bae, Han-Joon
• Cho, Hyun Jun
• Lee, Chan-Hee
• Bae, Myung Hwan
• Park, Hyoung-Seob
• Jung, Byung Chun
• Shin, Dong-Gu
• Cho, Yongkeun
• Hwang, Jongmin
• Han, Seongwook
• Park, Kyu-Hwan
• Jang, Se Yong
• Lee, Young Soo

Titel

Electrocardiographic Manifestations in Patients with COVID-19: Daegu in South Korea

Ist Teil von

• Korean Circulation Journal, 2021, 51(10), , pp.851-862

Ort / Verlag

The Korean Society of Cardiology

Erscheinungsjahr

2021

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• BACKGROUND AND OBJECTIVESAs the coronavirus disease 2019 (COVID-19) spreads worldwide, cardiac injury in patients infected with COVID-19 becomes a significant concern. Thus, this study investigates the impact of several electrocardiogram (ECG) parameters and disease severity in COVID-19 patients. METHODSSeven medical centers in Daegu admitted 822 patients with COVID-19 between February and April 2020. This study examined 267 patients among them who underwent an ECG test and evaluated their biochemical parameters like C-reactive protein (CRP), log N-terminal pro-B-type Natriuretic Peptide (NT-proBNP), cardiac enzyme, and ECG parameters (heart rate, PR interval, QRS interval, T inversion, QT interval, and Tpe [the interval between peak to end in a T wave]). RESULTSThose patients were divided into 3 groups of mild (100 patients), moderate (89 patients), and severe (78 patients) according to clinical severity score. The level of CRP, log NT-proBNP, and creatinine kinase-myocardial band were significantly increased in severe patients. Meanwhile, severe patients exhibited prolonged QT intervals (QTc) and Tpe (Tpe-c) compared to mild or moderate patients. Moreover, deceased patients (58; 21.7%) showed increased dispersion of QTc and Tpe-c compared with surviving patients (78.2±41.1 vs. 40.8±24.6 ms and 60.2±37.3 vs. 40.8±24.5 ms, both p<0.05, respectively). The QTc dispersion of more than 56.1 ms could predict the mortality in multivariate analysis (odd ratio, 11.55; 95% confidence interval, 3.746-42.306). CONCLUSIONSCOVID-19 infections could involve cardiac injuries, especially cardiac repolarization abnormalities. A prolonged QTc dispersion could be an independent predictable factor of mortality.