Details

Autor(en) / Beteiligte

• 전영희(Young-Hee Jeon)
• 남원희(Won-Hee Nam)
• 임현희(Hyun-Hee Leem)
• 김세진(Se-Jin Kim)
• 유병우(Byung-Woo Yu)
• 손수미(Su-Mi Son)
• 김명진(Myoung-Jin Kim)
• 최혜민(Hye-Min Choi)
• 권현숙(Hyun-Sook Kwon)
• 김정옥(Jung-Ok Kim)

Titel

제조방법에 따른 당귀수산(當歸鬚散)의 성분분석 및 항염증 효과

Ist Teil von

• 생약학회지, 2021, 52(3), 206, pp.192-201

Ort / Verlag

한국생약학회

Erscheinungsjahr

2021

Link zum Volltext

Quelle

Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals

Beschreibungen/Notizen

• Dangguisu-san (DGSS) is widely known traditional herbal medicinal formula in Korea for treatment of traumatic injury by traffic accident, ecchymosis, abdominal distension and anti-thrombosis of blood. This study was conducted to develop the simultaneous analyze method using high performance liquid chromatography (HPLC) and examine the effect of anti-inflammatory activity of DGSS-dry extract (DGSS-DE) and DGSS-mix extract powder (DGSS-MEP). Physicochemical characteristics of DGSS-DE and DGSS-MEP showed that there is no significant difference in pH, titratable acidity, total soluble solid content and browning degree except for color value (L, a, b). 15 functional constituents of DGSS were identified and the correlation coefficient values of DGSS-DE and DGSS-MEP were conformed 0.950. Also, DGSS-DE and DGSS-MEP significantly decreased the secretion of nitric oxide (NO), prostaglandin E2 (PGE2), interleukin-1β (IL-1β), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) through inhibited expression of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), IL-1β, IL-6, and TNF-α. From these result, DGSS-MEP showed similar chemical composition and anti-inflammatory effect to DGSS-DE. Therefore, DGSS-DE and DGSS-MEP may be useful as potential source of drug to prevent inflammation.