Details

Autor(en) / Beteiligte

• Nguyen, Van Quy
• You, Dong Gil
• Oh, Byeong Hoon
• Bui, Van Dat
• An, Jae Yoon
• Um, Wooram
• Park, Jae Hyung

Titel

Diselenide-Bearing Liposomes for Intracellular Delivery of a Vitamin C Derivative in Cancer Cells

Ist Teil von

• Macromolecular Research, 2021, 29(5), , pp.327-330

Ort / Verlag

Seoul: The Polymer Society of Korea

Erscheinungsjahr

2021

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Vitamin C, which promotes oxidative stress, has emerged as an alternative to conventional chemotherapy for treating cancers. However, owing to its cytotoxicity, vitamin C should be delivered to cells in its oxidized form, dehydroascorbate (DHA). Glutathione (GSH)-responsive nanoparticles (G-NPs) have been prepared as potential carriers of DHA by incorporating diselenide-based amphiphilic lipids into the liposomal membrane. Bare liposomes without diselenide-based lipids were prepared as control NPs; these exhibited particle sizes and surface charges comparable to those of G-NPs. DHA was physically encapsulated in NPs using the dehydration-rehydration method. DHA-loaded G-NPs induced much higher GSH depletion in HT29 colon cancer cells than DHA-loaded controls. Interestingly, DHA-loaded G-NPs significantly increased the intracellular levels of reactive oxygen species, implying enhanced oxidative stress by stimuli-responsive DHA release. Consequently, DHA-loaded G-NPs exhibited significant cytotoxicity against HT29 colon cancer cells. Overall, G-NPs might serve as potential carriers for intracellular delivery of DHA during cancer treatment.