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In vivo Skin Deposition and Photoprotection Effect of Genistein in Liposomal Gel Formulations
Ist Teil von
Journal of Pharmaceutical Investigation, 2008, 38(5), , pp.325-329
Ort / Verlag
한국약제학회
Erscheinungsjahr
2008
Beschreibungen/Notizen
To enhance the skin delivery of genistein (GT), a soybean isoflavone having antioxidative activity, comparative
formulation studies including liposomes were carried out. GT-loaded conventional and elastic liposomal gel showed the
enhanced skin deposition and photoprotection effect as well, in comparison to GT suspension. Elastic liposomes composed of
soybean phosphatidylcholine and sodium deoxycholate (85 :15 w/w%) were superior to conventional liposomes and were of
characteristics as follows: about 130 nm in size; 85% encapsulation efficiency of GT; 5.8% skin deposition of applied dose;
40% inhibition effect on UVB-induced H2O2 production. Photoprotection effect was closely related to skin deposition of GT.
In conclusion, it is possible to suggest that elastic liposomes could be a promising nanocarrier system for efficient skin delivery. KCI Citation Count: 0