Details

Autor(en) / Beteiligte

• Yong Min Kim
• Bo Gyun Kim
• 강명주
• Jae Yoon Eum
• 최영욱

Titel

In vivo Skin Deposition and Photoprotection Effect of Genistein in Liposomal Gel Formulations

Ist Teil von

• Journal of Pharmaceutical Investigation, 2008, 38(5), , pp.325-329

Ort / Verlag

한국약제학회

Erscheinungsjahr

2008

Beschreibungen/Notizen

• To enhance the skin delivery of genistein (GT), a soybean isoflavone having antioxidative activity, comparative formulation studies including liposomes were carried out. GT-loaded conventional and elastic liposomal gel showed the enhanced skin deposition and photoprotection effect as well, in comparison to GT suspension. Elastic liposomes composed of soybean phosphatidylcholine and sodium deoxycholate (85 :15 w/w%) were superior to conventional liposomes and were of characteristics as follows: about 130 nm in size; 85% encapsulation efficiency of GT; 5.8% skin deposition of applied dose; 40% inhibition effect on UVB-induced H2O2 production. Photoprotection effect was closely related to skin deposition of GT. In conclusion, it is possible to suggest that elastic liposomes could be a promising nanocarrier system for efficient skin delivery. KCI Citation Count: 0