Details

Autor(en) / Beteiligte

• Kwak, Se Hyun
• Choi, Ji Soo
• Lee, Eun Hye
• Lee, Su Hwan
• Leem, Ah Young
• Lee, Sang Hoon
• Kim, Song Yee
• Chung, Kyung Soo
• Kim, Eun Young
• Jung, Ji Ye
• Park, Moo Suk
• Kim, Young Sam
• Chang, Joon
• Kang, Young Ae

Titel

Characteristics and Treatment Outcomes of Isoniazid Mono-Resistant Tuberculosis: A Retrospective Study

Ist Teil von

• Yonsei Medical Journal, 2020, 61(12), , pp.1034-1041

Ort / Verlag

Korea (South): Yonsei University College of Medicine

Erscheinungsjahr

2020

Quelle

MEDLINE

Beschreibungen/Notizen

• Isoniazid (INH) mono-resistant tuberculosis (Hr-TB) is a highly prevalent type of drug-resistant TB, possibly associated with unfavorable treatment outcomes. However, definitive guidelines on an optimal treatment regimen and duration for Hr-TB are currently under discussion. We evaluated the characteristics and treatment outcomes of Hr-TB patients. We retrospectively reviewed the medical records of Hr-TB patients treated at a South Korean tertiary referral hospital from January 2005 to December 2018. We included 195 Hr-TB patients. 113 (57.9%) were male, and the median age was 56.6 [interquartile range, 40.2-68.6] years. Mutations in were the most frequent [54 (56.3%)], followed by those in the [34 (35.4%)]. Favorable and unfavorable outcomes were noted in 164 (84.1%) and 31 (15.9%) patients, respectively. Smoking history [odds ratio (OR)=5.606, 95% confidence interval (CI): 1.695-18.543, =0.005], low albumin level (OR=0.246, 95% CI: 0.104-0.578, =0.001), and positive acid-fast bacilli culture at 2 months (OR=7.853, 95% CI: 1.246-49.506, =0.028) were associated with unfavorable outcomes. A tailored strategy targeting high-risk patients is imperative for improved treatment outcomes. Further research on the rapid and accurate detection of resistance to INH and other companion drugs is warranted.