Applied Biological Chemistry, 2020, 63(3), , pp.1-9
2020
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Details
- Autor(en) / Beteiligte
- Titel
- Anti-inflammatory effect of hispidin on LPS induced macrophage inflammation through MAPK and JAK1/STAT3 signaling pathways
- Ist Teil von
- Applied Biological Chemistry, 2020, 63(3), , pp.1-9
- Ort / Verlag
- Singapore: Springer Singapore
- Erscheinungsjahr
- 2020
- Quelle
- Alma/SFX Local Collection
- Beschreibungen/Notizen
- Severe inflammatory reactions caused by macrophage activation can trigger a systemic immune response. In the present study, we observed the anti-inflammatory properties of hispidin on LPS induced RAW264.7 macrophage cells. Our results showed that hispidin treatment significantly reduced the production of cellular NO, IL-6 and reactive oxygen species (ROS) while has not inhibitory effect on TNF-α productions. Excitingly, hispidin treatment retains the phagocytosis ability of macrophages which enabling them to perform the function of removing foreign invaders. Signaling studies showed, hispidin treatment dramatic suppressed the LPS induced mitogen activated protein kinases (MAPK) and JAK/STAT activations. In conclusion, our findings suggest that hispidin may be a new therapeutic target for clinical treatment of macrophages-mediated inflammatory responses.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 2468-0834eISSN: 2468-0842DOI: 10.1186/s13765-020-00504-2Titel-ID: cdi_nrf_kci_oai_kci_go_kr_ARTI_9518610
- Format
- –
- Schlagworte
- Anti-inflammatory agents, Applied Microbiology, Biological Techniques, Bioorganic Chemistry, Cell activation, Cellular manufacture, Chemistry, Chemistry and Materials Science, Immune response, Inflammation, Interleukin 6, Janus kinase, Kinases, Lipopolysaccharides, Macrophages, MAP kinase, Phagocytosis, Reactive oxygen species, Signaling, Stat3 protein, Tumor necrosis factor-α, 농학