Details

Autor(en) / Beteiligte

• Wang, Yihui
• Hoffmann, Joseph P.
• Chou, Chau-Wen
• Höner zu Bentrup, Kerstin
• Fuselier, Joseph A.
• Bitoun, Jacob P.
• Wimley, William C.
• Morici, Lisa A.

Titel

Burkholderia thailandensis outer membrane vesicles exert antimicrobial activity against drug-resistant and competitor microbial species

Ist Teil von

• The Journal of Microbiology, 2020, 58(7), , pp.550-562

Ort / Verlag

Seoul: The Microbiological Society of Korea

Erscheinungsjahr

2020

Quelle

MEDLINE

Beschreibungen/Notizen

• Gram-negative bacteria secrete outer membrane vesicles (OMVs) that play critical roles in intraspecies, interspecies, and bacteria-environment interactions. Some OMVs, such as those produced by Pseudomonas aeruginosa , have previously been shown to possess antimicrobial activity against competitor species. In the current study, we demonstrate that OMVs from Burkholderia thailandensis inhibit the growth of drug-sensitive and drug-resistant bacteria and fungi. We show that a number of antimicrobial compounds, including peptidoglycan hydrolases, 4-hydroxy-3-methyl-2-(2-non-enyl)-quinoline (HMNQ) and long-chain rhamnolipid are present in or tightly associate with B. thailandensis OMVs. Furthermore, we demonstrate that HMNQ and rhamnolipid possess antimicrobial and antibiofilm properties against methicillin-resistant Staphylococcus aureus (MRSA). These findings indicate that B. thailandensis secretes antimicrobial OMVs that may impart a survival advantage by eliminating competition. In addition, bacterial OMVs may represent an untapped resource of novel therapeutics effective against bio-film-forming and multidrug-resistant organisms.