Details

Autor(en) / Beteiligte

• Lee, K.S., Konkuk University, Seoul, Republic of Korea
• Jeong, E.S., Konkuk University, Seoul, Republic of Korea
• Heo, S.H., Konkuk University, Seoul, Republic of Korea
• Seo, J.H., Konkuk University, Seoul, Republic of Korea
• Jeong, D.G., Konkuk University, Seoul, Republic of Korea
• Choi, Y.K., Konkuk University, Seoul, Republic of Korea

Titel

IL-10 suppresses bactericidal response of macrophages against Salmonella Typhimurium

Ist Teil von

• The Journal of Microbiology, 2011, 49(6), , pp.1050-1053

Ort / Verlag

Heidelberg: The Microbiological Society of Korea

Erscheinungsjahr

2011

Quelle

SpringerLink

Beschreibungen/Notizen

• We report, herein, an attempt to determine whether an IL-10-induced immunological state affects the response of macrophages against Salmonella Typhimurium (ST). Pretreatment with mrIL-10 induced the intracellular invasion of ST into macrophages in a dose-dependent manner. It also activated AKT phosphorylation, cyclin D1, Bcl-X∧L, and COX-2 upon ST infection, which may correlate with Salmonella's survival within the macrophages. However, I-κB phosphorylation was shown to be inhibited, along with the expression of TNF-α and MIP-2α mRNA. Therefore, IL-10 not only suppresses the bactericidal response of macrophages against ST, but also ultimately causes infected macrophages to function as hosts for ST replication.