Details

Autor(en) / Beteiligte

• Chul Jae Lee
• Jae Soo Kang
• Mak Soon Kim
• 이광필
• 이무상

Titel

The Study of Doxorubicin and its Complex with DNA by SERS and UV-resonance Raman Spectroscopy

Ist Teil von

• Bulletin of the Korean Chemical Society, 2004, 25(8), , pp.1211-1216

Ort / Verlag

대한화학회

Erscheinungsjahr

2004

Link zum Volltext

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• The interaction of the antitumour agent doxorubicin with calf thymus DNA is investigated in an aqueous solution at a pH level of 6-7 with molar ratios of 1/10. A UV-resonance Raman spectroscopy and surface enhanced Raman spectroscopy are used to determine the doxorubicin binding sites and the structural variations of doxorubicin-DNA complexes in an aqueous solution. Doxorubicin intercalates with adenine and guanine via a hydrogen bond formation between the N7 positions of purine bases and the hydroxyl group of doxorubicin. KCI Citation Count: 33