Details

Autor(en) / Beteiligte

• Jin, E.J. (Kyungpook National University, Daegu, Republic of Korea)
• Lee, S.Y. (Kyungpook National University, Daegu, Republic of Korea)
• Choi, Y.A. (Kyungpook National University, Daegu, Republic of Korea)
• Jung, J.C. (Kyungpook National University, Daegu, Republic of Korea)
• Bang, O.S. (Seoul National University, Seoul, Republic of Korea)
• Kang, S.S. (Kyungpook National University, Daegu, Republic of Korea), E-mail: kangss@knu.ac.kr

Titel

BMP-2-Enhanced Chondrogenesis Involves p38 MAPK-mediated Down-Regulation of Wnt-7a Pathway

Ist Teil von

• Molecules and Cells, 2006, 22(3), , pp.353-359

Ort / Verlag

United States: 한국분자세포생물학회

Erscheinungsjahr

2006

Quelle

MEDLINE

Beschreibungen/Notizen

• The bone morphogenetic protein (BMP) family has been implicated in control of cartilage development. Here, we demonstrate that BMP-2 promotes chondrogenesis by activating p38 mitogen-activated protein kinase (MAPK), which in turn downregulates Wnt-7a/β-catenin signaling responsible for proteasomal degradation of Sox9. Exposure of mesenchymal cells to BMP-2 resulted in upregulation of Sox9 protein and a concomitant decrease in the level of β-catenin protein and Wnt-7a signaling. In agreement with this, the interaction of Sox9 with β-catenin was inhibited in the presence of BMP-2.