Details

Autor(en) / Beteiligte

• Park, C.N., Kyungpook National University, Daegu, Republic of Korea
• Woo, E.R., Chosun University, Gwangju, Republic of Korea
• Lee, D.G., Kyungpook National University, Daegu, Republic of Korea

Titel

Anti-Candida Property of a Lignan Glycoside Derived from Styrax japonica S. et Z. via Membrane-Active Mechanisms

Ist Teil von

• Molecules and Cells, 2010, 29(6), , pp.581-584

Ort / Verlag

Springer: Korean Society for Molecular and Cellular Biology

Erscheinungsjahr

2010

Quelle

MEDLINE

Beschreibungen/Notizen

• Styraxjaponoside C was investigated with respect to its antifungal activity and mechanisms of action. Devoid of hemolytic activity, Styraxjaponoside C demonstrated an antifungal effect against the human pathogenic yeast Candida albicans in an energy-independent manner. To characterize the mechanisms of the antifungal activity of Styraxjaponoside C, fluorescence analysis with membrane probe 1,6-diphenyl-1,3,5-hexatriene, and flow cytometric analysis on C. albicans were conducted. The results showed that Styraxjaponosdie C induced cytoplasmic membrane perturbation. The current study suggested that Styraxjaponoside C was active against C. albicans with membrane-active mechanisms.