Details

Autor(en) / Beteiligte

• 박경미
• 곽호현
• 남현숙
• 박인철
• 전용환
• 박성민
• 이승태
• 우제석
• 우흥명
• Park, Kyung-Mee
• Kwak, Ho-Hyun
• Nam, Hyun-Suk
• Park, In-Chul
• Jeon, Yong-Hwan
• Park, Sung-Min
• Lee, Seung-Tae
• Woo, Jae-Seok
• Woo, Heung-Myong

Titel

탈세포화 기법을 이용한 돼지 바이오 스캐폴드: 환자 맞춤형 장기재생을 위한 역분화 줄기세포 동물모델

Ist Teil von

• 한국임상수의학회지, 2011, 28(1), , pp.57-62

Ort / Verlag

한국임상수의학회

Erscheinungsjahr

2011

Link zum Volltext

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• The shortage of transplantable kidneys has many efforts to regenerate bioartificial kidneys using transgenic animals and diverse kinds of scaffolds which are important tools for cell seeding. However, there are many limitations for clinical applications so far. Recently, decellularized bioscaffolds using animal organs come into spotlight because of its many superior advantages. In current study, we produced decellularized kidney bioscaffolds of pig which is an attractive animal as a clinical model for human. We decellularized pig kidneys with 1% SDS detergent solution using peristaltic pump systems for 12h. After decellularization process, the kidney bioscaffolds preserved intact 3D morphology including glomerular structure and almost DNA from pig was entirely removed. In addition, this process could preserve micro vascular network which is necessary for cell survival. Although, additional studies for recellularization and transplantation should be required, the decellular vascularized kidney bioscaffolds might have many potentials for kidney regeneration.