Details

Autor(en) / Beteiligte

• Ohtori, Seiji
• Inoue, Gen
• Orita, Sumihisa
• Eguchi, Yawara
• Ochiai, Nobuyasu
• Kishida, Shunji
• Takaso, Masashi
• Aoki, Yasuchika
• Kuniyoshi, Kazuki
• Nakamura, Junichi
• Ishikawa, Tetsuhiro
• Arai, Gen
• Miyagi, Masayuki
• Kamoda, Hiroto
• Suzuki, Miyako
• Toyone, Tomoaki
• Takahashi, Kazuhisa

Titel

Transdermal fentanyl for chronic low back pain

Ist Teil von

• Yonsei Medical Journal, 2012, 53(4), , pp.788-793

Ort / Verlag

Korea (South): Yonsei University College of Medicine

Erscheinungsjahr

2012

Quelle

MEDLINE

Beschreibungen/Notizen

• Chronic low back pain is a common clinical problem. As medication, non-steroidal anti-inflammatory drugs are generally used; however, they are sometimes non-effective. Recently, opioids have been used for the treatment of chronic low back pain, and since 2010, transdermal fentanyl has been used to treat chronic non-cancer pain in Japan. The purpose of the current study was to examine the efficacy of transdermal fentanyl in the treatment of chronic low back pain. This study included patients (n=62) that suffered from chronic low back pain and were non-responsive to non-steroidal anti-inflammatory drugs. Their conditions consisted of non-specific low back pain, multiple back operations, and specific low back pain awaiting surgery. Patients were given transdermal fentanyl for chronic low back pain. Scores of the visual analogue scale and the Oswestry Disability Index, as well as adverse events were evaluated before and after therapy. Overall, visual analogue scale scores and Oswestry Disability Index scores improved significantly after treatment. Transdermal fentanyl (12.5 to 50 μg/h) was effective in reducing low back pain in 45 of 62 patients; however, it was not effective in 17 patients. Patients who experienced the most improvement were those with specific low back pain awaiting surgery. Adverse events were seen in 40% of patients (constipation, 29%; nausea, 24%; itching, 24%). Transdermal fentanyl significantly improved visual analog scale scores and Oswestry Disability Index scores in 73% of patients, especially those with specific low back pain awaiting surgery; however, it did not decrease pain in 27% of patients, including patients with non-specific low back pain or multiple back operations.