Details

Autor(en) / Beteiligte

• 남경수(Kyung Soo Nam)
• 손옥례(Ok Lye Son)
• 이경화(Kyung Hwa Lee)
• 조현정(Hyun Jung Cho)
• 손윤희(Yun Hee Shon)

Titel

천궁이 유방암세포 증식, Nitric Oxide 생성 및 Ornithine Decarboxylase 활성에 미치는 영향

Ist Teil von

• 생약학회지, 2004, 35(4), , pp.283-287

Ort / Verlag

한국생약학회

Erscheinungsjahr

2004

Link zum Volltext

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• The effect of water extract from Cnidii Rhizoma (CRW) on proliferation of human breast cancer cells, nitric oxide production, nitric oxide synthase expression, and ornithine decarboxylase activity was tested. CRW inhibited the growth of both estrogen-dependent MCF-7 and estrogen-independent MDA-MB-23I human breast cancer cells. Lipopolysaccharide-induced nitric oxide (NO) production was significantly reduced by CRW at the concentration of 0.5, 1.0 and 5.0 mg/ml. Expression of inducible nitric oxide synthase (iNOS) was also suppressed with the treatment of CRW in Raw 264.7 cells. CRW inhibited induction of ornithine decarboxylase by 12-0-tetradecanoylphorbol-13-acetate, a key enzyme of polyamine biosynthesis, which is enhanced in tumour promotion. Therefore, CRW is worth further investigation with respect to breast cancer chemoprevention or therapy.