Details

Autor(en) / Beteiligte

• 윤구(Goo Yoon)
• 김수남(Su Nam Kim)
• 천승훈(Seung Hoon Cheon)
• 강복윤(Bok Yun Kang)
• 심정현(Jung Hyun Shim)
• 조승식(Seung Sik Cho)
• 임현진(Hyun Jin Lim)
• 김현정(Hyun Jung Kim)
• 정유정(Yujung Jung)
• 윤인수(In Soo Yoon)

Titel

고지방식이 유발 제2형 당뇨모델 마우스에서 작약의 혈당강하 효능

Ist Teil von

• 생약학회지, 2014, 45(3), , pp.194-199

Ort / Verlag

한국생약학회

Erscheinungsjahr

2014

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• The roots of Paeonia lactiflora (PL) has been traditionally used as analgesic, spasmolytic and tonic in Korea, China, and Japan. As part of a search for herbal medicine to treat diabetes and obesity, we confirmed hypoglycemic effect of PL through high fat diet-induced obese and diabetic mice experiments in vivo. Treatment of ethanolic extract from PL led to a significant decrease in glucose level, which is comparable to that of an antidiabetic drug metformin. In addition, PL selectively stimulates the transcriptional activities of both peroxisome proliferator-activated receptor $(PPAR){\alpha}$ and ${\gamma}$, and inhibits enzymatic activity of protein tyrosine phosphatase 1B (PTP1B), which are predicted to be therapeutic target in treatment of type2 diabetes and obesity. Especially, the n-hexane fraction (Hx) from PL ethanol extract showed more potent activities on $PPAR{\alpha}$ and than others and exihibited moderate inhibitory activity against PTP1B.