Details

Autor(en) / Beteiligte

• Kim, J.E., University of Connecticut, Storrs, CT, USA
• Clark, Richard M., University of Connecticut, Storrs, CT, USA
• Park, Y.K., University of Connecticut, Storrs, CT, USA
• Lee, J.Y., University of Connecticut, Storrs, CT, USA
• Fernandez, Maria Luz, University of Connecticut, Storrs, CT, USA

Titel

Lutein decreases oxidative stress and inflammation in liver and eyes of guinea pigs fed a hypercholesterolemic diet

Ist Teil von

• Nutrition Research and Practice, 2012, 6(2), , pp.113-119

Ort / Verlag

Korea (South): 한국영양학회

Erscheinungsjahr

2012

Link zum Volltext

Quelle

EZB Free E-Journals

Beschreibungen/Notizen

• Guinea pigs were fed a hypercholesterolemic diet (0.25 g/100 g cholesterol) and randomly allocated either to a Control group (n = 9) or to a Lutein (0.1 g/100 g) group (n = 10) for 12 weeks to evaluate oxidative stress and inflammation in both liver and eyes. Malondialdehyde (MDA) concentrations and inflammatory cytokines were measured as well as hepatic nuclear factor-kappaB (NF-κB) binding. Lutein concentrations were greater in eyes (P less than 0.01) and liver (P less than 0.001) in the Lutein group. All guinea pigs had high concentrations of hepatic cholesterol as well as high plasma ALT and AST levels indicative of liver injury. However, the Lutein group had 43% lower hepatic free cholesterol than the Controls (P less than 0.05). Hepatic MDA and MDA in the eye were lower in the Lutein compared to the Control group (P less than 0.05). Hepatic tumor necrosis factor-a was 32% lower in the Lutein group (P less than 0.05). Lastly, the Lutein group presented lower NF-κB DNA binding activity than the Control group (P less than 0.001). These results suggest that in the presence of high cholesterol, lutein exerts both antioxidant and anti-inflammatory effects, which can be explained by attenuated NF-κB DNA binding activity. Furthermore, results also suggest that lutein accumulates in the eyes of guinea pigs to protect against oxidative stress.