Details

Autor(en) / Beteiligte

• Choi, Won-Sun
• Lim, Eun-Soo
• Ban, Ga-Young
• Kim, Ji-Hye
• Shin, Yoo-Seob
• Park, Hae-Sim
• Ye, Young-Min

Titel

Disease-specific impairment of the quality of life in adult patients with chronic spontaneous urticaria

Ist Teil von

• The Korean Journal of Internal Medicine, 2018, 33(1), , pp.185-192

Ort / Verlag

Korea (South): The Korean Association of Internal Medicine

Erscheinungsjahr

2018

Quelle

MEDLINE

Beschreibungen/Notizen

• Chronic urticaria (CU) is a common skin disorder characterized by wheals and pruritus lasting more than 6 weeks. Due to its long duration and changeable symptoms, the quality of life (QOL) of patients with CU can be impaired substantially. We evaluated the CU-QOL, a previously validated CU-specific QOL measure, and investigated factors influencing QOL in chronic spontaneous urticaria (CSU) patients. A hospital-based cross-sectional study was performed on 390 adult patients diagnosed with CSU from March 2009 to December 2012 at the Allergy and Clinical Immunology Clinic at Ajou University Hospital. The CU-QOL questionnaire, urticaria activity score (UAS), combined angioedema, and serum total immunoglobulin E (IgE) levels were investigated. The average CU-QOL score obtained from the questionnaire was 70.6 (of 100 points). The CU-QOL scores correlated significantly with the UAS, particularly with the 15-point UAS (UAS-15; coefficient -0.532, < 0.01) rather than the 6-point UAS (-0.502, < 0.01). The patients presenting with angioedema and urticaria had poorer scores in the urticaria symptom domain than those with urticaria alone (37.4 vs. 46.9, = 0.004). Log-transformed serum total IgE levels correlated significantly with CU-QOL (-0.131, < 0.05). Multivariate regression models indicated that severe CU (UAS-15 score ≥ 13), log (total IgE), and the presence of angioedema were significant predictors of impaired CU-QOL (< 85 points). CU has a substantial negative impact on QOL. The assessment of UAS-15, total IgE, and the presence of angioedema can be useful to predict QOL of the patients with CSU.