Details

Autor(en) / Beteiligte

• Lee, Jinmi
• Hong, Seok-Woo
• Rhee, Eun-Jung
• Lee, Won-Young

Titel

GLP-1 Receptor Agonist and Non-Alcoholic Fatty Liver Disease

Ist Teil von

• Diabetes and Metabolism Journal, 2012, 36(4), 132, pp.262-267

Ort / Verlag

Korea (South): Korean Diabetes Association

Erscheinungsjahr

2012

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Non-alcoholic fatty liver disease (NAFLD), one of the most common liver diseases, is caused by the disruption of hepatic lipid homeostasis. It is associated with insulin resistance as seen in type 2 diabetes mellitus. Glucagon-like peptide-1 (GLP-1) is an incretin that increases insulin sensitivity and aids glucose metabolism. In recent in vivo and in vitro studies, GLP-1 presents a novel therapeutic approach against NAFLD by increasing fatty acid oxidation, decreasing lipogenesis, and improving hepatic glucose metabolism. In this report, we provide an overview of the role and mechanism of GLP-1 in relieving NAFLD.