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Exploitation of reactive oxygen species by fungi: roles in host-fungus interaction and fungal development
Ist Teil von
Journal of Microbiology and Biotechnology, 2014, 24(11), , pp.1455-1463
Ort / Verlag
Korea (South): 한국미생물·생명공학회
Erscheinungsjahr
2014
Quelle
MEDLINE
Beschreibungen/Notizen
In the past, reactive oxygen species (ROS) have been considered a harmful byproduct of aerobic metabolism. However, accumulating evidence implicates redox homeostasis, which maintains appropriate ROS levels, in cell proliferation and differentiation in plants and animals. Similarly, ROS generation and signaling are instrumental in fungal development and host-fungus interaction. In fungi, NADPH oxidase, a homolog of human gp91(phox), generates superoxide and is the main source of ROS. The mechanism of activation and signaling by NADPH oxidases in fungi appears to be largely comparable to those in plants and animals. Recent studies have shown that the fungal NADPH oxidase homologs NoxA (Nox1), NoxB (Nox2), and NoxC (Nox3) have distinct functions. In particular, these studies have consistently demonstrated the impact of NoxA on the development of fungal multicellular structures. Both NoxA and NoxB (but not NoxC) are involved in host-fungus interactions, with the function of NoxA being more critical than that of NoxB.