Details

Autor(en) / Beteiligte

• Leem, Ah Young
• Park, Moo Suk
• Park, Byung Hoon
• Jung, Won Jai
• Chung, Kyung Soo
• Kim, Song Yee
• Kim, Eun Young
• Jung, Ji Ye
• Kang, Young Ae
• Kim, Young Sam
• Kim, Se Kyu
• Chang, Joon
• Song, Joo Han

Titel

Value of Serum Cystatin C Measurement in the Diagnosis of Sepsis-Induced Kidney Injury and Prediction of Renal Function Recovery

Ist Teil von

• Yonsei Medical Journal, 2017, 58(3), , pp.604-612

Ort / Verlag

Korea (South): Yonsei University College of Medicine

Erscheinungsjahr

2017

Quelle

MEDLINE

Beschreibungen/Notizen

• Acute kidney injury (AKI) is common in critically ill patients. Serum cystatin C has emerged as a reliable marker of AKI. We sought to assess the value of serum cystatin C for early detection and prediction of renal function recovery in patients with sepsis. Sepsis patients (113 AKI patients and 49 non-AKI patients) admitted to the intensive care unit (ICU) were included. Serum creatinine and cystatin C levels and glomerular filtration rate were measured on days 0, 1, 3, and 7. Serum cystatin C levels were significantly higher in AKI patients than in non-AKI patients at all time points. Multivariate analysis showed that only serum cystatin C levels on day 0 were associated with AKI development [odds ratio (OR)=19.30; 95% confidence interval (CI)= 2.58-144.50, p<0.001]. Linear mixed model analysis showed significant variation in cystatin C levels between the recovery and non-recovery groups over time (p=0.001). High levels of serum cystatin C at day 0 (OR=1.64; 95% CI=1.00-2.68, p=0.048) were associated with recovery of AKI. Serum cystatin C level was found to be associated with the development and worsening of AKI in ICU patients with sepsis.